【teen patti indian poker exe download】定制mRNA载体可快速创建并自带“导航”
?导航 科技日报北京7月11日电 (记者张梦然)美国宾夕法尼亚大学研究团队利用“点击化学”技术,通过一个简单步骤创建出脂质纳米颗粒(LNP)。定制发表在最新一期《自然·化学》杂志上的载体自带teen patti indian poker exe download这项研究表明,其不仅加快了合成过程,可快还提供了一种为这些输送载体配备“导航”的速创方法,以更精确地实现对肝、建并肺和脾等特定器官的导航输送,为治疗这些器官中出现的定制疾病开辟了新途径。 mRNA携带遗传指令在细胞内产生特定的载体自带teen patti indian poker exe download蛋白质,这些蛋白质可诱导所需的可快免疫反应。LNP则是速创一种隐蔽的递送载体,可将这些脆弱的建并mRNA分子通过血液运输到其靶细胞。然而,导航阳离子脂质(一种带正电的定制脂质分子,是载体自带LNP的关键成分)的合成通常非常耗时,其涉及化学合成和纯化等多个步骤。 此次新开发的脒掺入可降解(AID)脂质,是一种结构独特的可生物降解分子。可把它想象成一个易于构建的定制mRNA载体,带有车身套件和“导航”系统。团队通过调整其形状和可降解性,可安全地向细胞递送mRNA。其可以被引导到身体的不同器官,就像将不同的目的地编程到“导航”中一样。 与传统上需要数周的过程相比,新方法可在短短一小时内快速创建不同的脂质结构。团队合成了100种不同的AID脂质,然后将其配制成LNP。他们在动物模型中测试了由此产生的LNP将mRNA递送至各种器官的能力,表明新方法可高精度地靶向特定器官。 团队还探索了该成果未来在mRNA疫苗研发中的潜力。结果证明,这些LNP可选择性地转染脾脏中的抗原呈递细胞(这是诱导强大免疫反应的关键步骤)。这一发现为开发基于mRNA的疫苗开辟了新的可能性。
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